4-Hydroxyisoleucine (Standard)
4-Hydroxyisoleucine (Standard) is the analytical standard of 4-Hydroxyisoleucine. This product is intended for research and analytical applications. 4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties[1].
Product Specifications
CAS Number
781658-23-9
Product Name Alternative
4-Hydroxy-L-isoleucine (Standard)
UNSPSC
12352211
Target
Others; Reference Standards
Type
Reference Standards
Related Pathways
Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxyisoleucine-standard.html
Smiles
N[C@@H]([C@@H](C)C(O)C)C(O)=O
Molecular Formula
C6H13NO3
Molecular Weight
147.17
References & Citations
[1]Haeri MR, et al. The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats. Phytother Res. 2009 Jan;23 (1) :61-4. |[2]Zhou C, et al. 4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation. BMC Complement Med Ther. 2020 Dec 9;20 (1) :373.|[3]Jaiswal N, et al. 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway. Eur J Nutr. 2012 Oct;51 (7) :893-8.|[4]Yang J, et al. 4-Hydroxyisoleucine Alleviates Macrophage-Related Chronic Inflammation and Metabolic Syndrome in Mice Fed a High-Fat Diet. Front Pharmacol. 2021 Jan 21;11:606514.|[5]Haeri MR, et al. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine. 2012 May 15;19 (7) :571-4.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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