CL-387785
CL-387785 (EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370 pM.
Product Specifications
CAS Number
194423-06-8
Product Name Alternative
EKI-785; WAY-EKI 785
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CL-387785.html
Purity
98.05
Solubility
DMSO : 13.67 mg/mL (ultrasonic; warming)
Smiles
O=C(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)C#CC
Molecular Formula
C18H13BrN4O
Molecular Weight
381.23
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Discafani CM, et al. Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[ (3-bromophenyl) amino]-6-quinazolinyl]-2-butynamide (CL-387,785) . Biochem Pharmacol. 1999 Apr 15;57 (8) :917-25.|[2]Sweeney WE, et al. Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int. 2000 Jan;57 (1) :33-40.|[3]Greulich H, et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2005 Nov;2 (11) :e313.|[4]Kobayashi S, et al. An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer Res. 2005 Aug 15;65 (16) :7096-101.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740034-100 1x 100 µL
Cytokeratin 8/18 (C-51), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040009-500 1x 500 µL
MART-1 / Melan-A (M2-7C10), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472216-100 1x 100 µL
CD50 / ICAM3 (CG106), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400034-100 1x 100 µL
Cytokeratin 8/18 (C-51), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402398-100 1x 100 µL
SOX9 / SRY-box 9 (SOX9/2398), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details