VH 032 amide-alkylC6-acid
VH 032 amide-alkylC6-acid ((S, R, S) -AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[2172819-75-7]
Product Name Alternative
(S, R, S) -AHPC-CO-C6-COOH
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vh-032-amide-alkylc6-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCCC(O)=O)=O)=O)C[C@H](O)C3
Molecular Formula
C30H42N4O6S
Molecular Weight
586.74
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer, WO2018081530A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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