Perillyl alcohol

Perillyl alcohol is an orally active monoterpene. Perillyl alcohol exhibits multiple activities such as analgesic, anti-inflammatory, anti-tumor, anti-angiogenic, and anti-nociceptive effects. Perillyl alcohol can induce apoptosis and cell cycle arrest in tumor cells[1][2][3][4].

Product Specifications

CAS Number

[536-59-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Caspase; Ras; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/perillyl-alcohol.html

Purity

95.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCC1=CCC(C(C)=C)CC1

Molecular Formula

C10H16O

Molecular Weight

152.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Loutrari H, et al. Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther. 2004 Nov;311 (2) :568-75.|[2]Lluria-Prevatt M, et al. Effects of perillyl alcohol on melanoma in the TPras mouse model. Cancer Epidemiol Biomarkers Prev. 2002 Jun;11 (6) :573-9.|[3]Benedito R B, et al. Perillyl alcohol: antinociceptive effects and histopathological analysis in rodent brains. Natural Product Communications, 2017, 12 (9) : 1934578X1701200902.|[4]Chen TC, et al. Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res. 2015 Apr 15;5 (5) :1580-93.