RAS/RAS-RAF-IN-1
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
[2447039-81-6]
UNSPSC
12352005
Target
Raf; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ras-ras-raf-in-1.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC(C)(C1=CN(CC(C)(COC([C@@](CCC2)([H])NN2C3=O)=O)C)C4=CC(C5=CC(O)=CC(C[C@@H]3NC([C@H](C(C)C)N(C)C([C@@H](CC6)CN6C(C=C)=O)=O)=O)=C5)=CC=C41)C#N
Molecular Formula
C45H57N7O7
Molecular Weight
807.98
References & Citations
[1]Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Raf; Ras
Available Sizes
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