JMV 449

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

Product Specifications

CAS Number

[139026-66-7]

UNSPSC

12352209

Target

Neurotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jmv-449.html

Solubility

10 mM in DMSO

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H]2N(C([C@H](CCCCN)NC[C@@H](N)CCCCN)=O)CCC2)=O)=O)=O

Molecular Formula

C38H66N8O7

Molecular Weight

746.98

References & Citations

[1]Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205 (2) :191-198.|[2]Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin- (8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219 (2) :327-329.