Desmethyl Bosentan

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013) .1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.

Product Specifications

CAS Number

[253688-61-8]

Product Name Alternative

Ro 47-8634

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450; Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/desmethyl-bosentan.html

Smiles

O=S(NC1=C(OC2=C(O)C=CC=C2)C(OCCO)=NC(C3=NC=CC=N3)=N1)(C4=CC=C(C(C)(C)C)C=C4)=O

Molecular Formula

C26H27N5O6S

Molecular Weight

537.59

Precautions

P264-P270-P330-P501

References & Citations

[1]van Giersbergen, et al. Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. Br. J. Clin. Pharmacol. 54 (5), 561-562 (2002) .