Tanogitran

Tanogitran is a dual inhibitor targeting Factor Xa and thrombin (thrombin), with Ki values of 26 and 2.7 nM, respectively. Tanogitran exhibits anticoagulant activity and can be used for research in thrombotic diseases[1][2].

Product Specifications

CAS Number

[637328-69-9]

UNSPSC

12352005

Target

Factor Xa

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tanogitran.html

Smiles

O=C(N1CCCC1)[C@@](C)(C2=CC=C(N(C(CNC3=CC=C(C=C3)C(N)=N)=N4)C)C4=C2)NCC(O)=O

Molecular Formula

C25H31N7O3

Molecular Weight

477.56

References & Citations

[1]Gómez-Outes A, et al. New parenteral anticoagulants in development. Ther Adv Cardiovasc Dis. 2011 Feb;5 (1) :33-59. |[2]Remko M, et al. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors. Molecules. 2016 Feb 4;21 (2) :185.