Phospho-PLCγ1 (Tyr783) Rabbit APC Conjugate

<strong>Phospho-PLCγ1 (Tyr783) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018494_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, Phospholipase C-gamma-1, PLC-gamma-1, PLC1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Portillo JC, Yu JS, Vos S, Bapputty R, Lopez Corcino Y, Hubal A, Daw J, Arora S, Sun W, Lu ZR, Subauste CS. Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells Diabetologia. 2022 Dec;65(12):2157-2171._x000D_ 2: Vos S, Aaron R, Weng M, Daw J, Rodriguez-Rivera E, Subauste CS. CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):17._x000D_ 3: Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S. Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1 J Biol Chem. 2009 Mar 27;284(13):8951-62._x000D_ 4: Nosbisch JL, Bear JE, Haugh JM. A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation J Biol Chem. 2022 May;298(5):101886._x000D_ 5: Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek J. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes Biochemistry. 2013 Jul 16;52(28):4810-9._x000D_ 6: Pei ZD, Williamson JR. Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells FEBS Lett. 1998 Feb 13;423(1):53-6._x000D_ 7: Koss H, Bunney TD, Esposito D, Martins M, Katan M, Driscoll PC. Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR Biophys J. 2018 Jul 3;115(1):31-45._x000D_ 8: Choi JH, Hong WP, Yun S, Kim HS, Lee JR, Park JB, Bae YS, Ryu SH, Suh PG. Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1 Cell Signal. 2005 Oct;17(10):1289-99._x000D_ 9: Ren K, Ma Y, Huang Y, Liang W, Liu F, Wang Q, Cui W, Liu Z, Yin G, Fan W. Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1 Braz J Med Biol Res. 2011 Dec;44(12):1231-42._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29154981">10: Mora Vidal R, Regufe da Mota S, Hayden A, Markham H, Douglas J, Packham G, Crabb SJ. Epidermal Growth Factor Receptor Family Inhibition Identifies P38 Mitogen-activated Protein Kinase as a Potential Therapeutic Target in Bladder Cancer Urology. 2018 Feb;112:225.e1-225.e7. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-PLCγ1 (Tyr783) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>