BI1002494
BI1002494 is an orally active, potent, and selective spleen tyrosine kinase (SYK) inhibitor. BI 1002494 exhibits an IC50 of 115 nM in inhibiting high-affinity IgE receptor-mediated mast cell and basophil degranulation. BI1002494 can be utilized in immunology reesearch[1].
Product Specifications
CAS Number
1319738-39-0
UNSPSC
12352005
Target
Syk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bi1002494.html
Smiles
O=C1NC[C@@H](C1)[C@@H](C)OC2=C3C=CC=NC3=CC(C4=CC(OC)=C(C(OC)=C4)OC)=N2
Molecular Formula
C23H25N3O5
Molecular Weight
423.46
References & Citations
[1]Lamb DJ, et al. BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells. J Pharmacol Exp Ther. 2016 Jun;357 (3) :554-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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