FR900098

FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice[1].

Product Specifications

CAS Number

[66508-32-5]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fr900098.html

Solubility

10 mM in DMSO

Smiles

O=C(N(O)CCCP(=O)(O)O)C

Molecular Formula

C5H12NO5P

Molecular Weight

197.13

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wiesner J, et al. FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence. 2016 Aug 17;7 (6) :718-28.