BAY1082439
Product Specifications
UNSPSC Description
BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2].
Target Antigen
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay1082439.html
Purity
98.02
Solubility
0.1 M HCL : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)|DMSO : 5 mg/mL (ultrasonic;adjust pH to 5 with HCl)
Smiles
O=C(C1=CC=CN=C1C)NC2=NC3=C(C=CC(OC[C@H](O)CN4CCOCC4)=C3OC)C5=NCCN25
Molecular Weight
494.54
References & Citations
[1]Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.|[2]Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100886/BAY1082439-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100886/BAY1082439-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1375469-38-7
Available Sizes
Curated Selection
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