OATD-02 (hydrochloride)
OATD-02 hydrochloride is the hydrochloride salt form of OATD-02. OATD-02 hydrochloride an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 hydrochloride bolishes tumor immunosuppression induced by both arginases. OATD-02 hydrochloride can be used for melanoma study[1].
Product Specifications
UNSPSC
12352211
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oatd-02-hydrochloride.html
Purity
99.88
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C.[H]Cl
Molecular Formula
C12H26BClN2O4
Molecular Weight
308.61
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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