Rivenprost
Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects[1][2].
Product Specifications
CAS Number
256382-08-8
Product Name Alternative
ONO-4819; ONO-AE1-734
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/rivenprost.html
Concentration
2.22 mM * 500 μL in Methyl acetate
Purity
99.0
Solubility
10 mM in DMSO
Smiles
COCC1=CC=CC(C[C@H](O)/C=C/[C@@H]2[C@H](C(C[C@H]2O)=O)CCSCCCC(OC)=O)=C1
Molecular Formula
C24H34O6S
Molecular Weight
450.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Ninomiya T, et al., Prostaglandin E (2) receptor EP (4) -selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation. Eur J Pharmacol. 2011 Jan 10;650 (1) :396-402.|[2]Kasai K, et al., A novel prostaglandin E receptor subtype agonist, 0N0-4819, attenuates acute experimental liver injury in rats. Hepatol Res. 2001 Nov;21 (3) :252-260.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
EP
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