SHS206
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that reduces hepatic triglyceride levels. SHS206 exhibits in vivo efficacy in the GAN mouse model and shows inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH) [1].
Product Specifications
UNSPSC
12352005
Target
Mitophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/shs206.html
Smiles
FC(OC1=CC=CC(C2=C3C(N=C(C(F)(F)F)N3)=NC=C2)=C1)(F)F
Molecular Formula
C14H7F6N3O
Molecular Weight
347.22
References & Citations
[1]Salamoun J M, et al. Design, synthesis, and biological evaluation of imidazo [4, 5-b] pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) [J]. European Journal of Medicinal Chemistry, 2024, 280: 116916.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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