Guaifenesin

Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].

Product Specifications

CAS Number

[93-14-1]

Product Name Alternative

Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate

UNSPSC

12352005

Hazard Statement

H302

Target

Mucin

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Guaifenesin.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

OCC(O)COC1=CC=CC=C1OC

Molecular Formula

C10H14O4

Molecular Weight

198.22

Precautions

H302

References & Citations

[1]Bennett, S., N. Hoffman, and M. Monga, Ephedrine- and guaifenesin-induced nephrolithiasis. J Altern Complement Med, 2004. 10 (6) : p. 967-9.|[2]Dicpinigaitis PV, et, al. Effect of guaifenesin on cough reflex sensitivity. Chest. 2003 Dec;124 (6) :2178-81.|[3]Seagrave J, et al. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res. 2011 Dec;37 (10) :606-14.|[4]Seagrave J, et al. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir Res. 2012 Oct 31;13 (1) :98.|[5]Kagan L, et al. Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm Pharmacol Ther. 2009 Jun;22 (3) :260-5.