PF-01247324

PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.

Product Specifications

CAS Number

[875051-72-2]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PF-01247324.html

Purity

99.77

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O=C(C1=NC(N)=C(C2=CC(Cl)=CC(Cl)=C2Cl)C=C1)NC

Molecular Formula

C13H10Cl3N3O

Molecular Weight

330.60

Precautions

H301, H315, H319, H335

References & Citations

[1]Payne CE, et al. A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability. Br J Pharmacol. 2015 May;172 (10) :2654-70.|[2]Shields SD, et al. Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis. PLoS One. 2015 Mar 6;10 (3) :e0119067.