SARS-CoV-2 NSP8 Protein

<strong>SARS-CoV-2 NSP8 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2013087_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 22.0 kDa_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> SARS-CoV-2 NSP8_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Yan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z. Architecture of a SARS-CoV-2 mini replication and transcription complex Nat Commun. 2020 Nov 18;11(1):5874._x000D_ 2: Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q, Lou Z, Rao Z. Structure of the RNA-dependent RNA polymerase from COVID-19 virus Science. 2020 May 15;368(6492):779-782._x000D_ 3: Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B. A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase Nat Commun. 2022 Feb 2;13(1):621._x000D_ 4: Ng TI, Correia I, Seagal J, DeGoey DA, Schrimpf MR, Hardee DJ, Noey EL, Kati WM. Antiviral Drug Discovery for the Treatment of COVID-19 Infections Viruses. 2022 May 4;14(5):961._x000D_ 5: Sarma H, Jamir E, Sastry GN. Protein-protein interaction of RdRp with its co-factor NSP8 and NSP7 to decipher the interface hotspot residues for drug targeting: A comparison between SARS-CoV-2 and SARS-CoV J Mol Struct. 2022 Jun 5;1257:132602._x000D_ 6: Yeo G, Xiang J, Mueller J, Luo EC, Yee B, Schafer D, Schmok J, Tan F, Rothamel K, McVicar R, Kwong E, Croker B, Jones K, Her HL, Chen CY, Vu A, Jin W, Park S, Le P, Brennan K, Kofman E, Li Y, Tankka A, Dong K, Song Y, Clark A, Carlin A, Nostrand EV, Leibel S. Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions Res Sq. 2022 Mar 17:rs.3.rs-1394331._x000D_ 7: Xiang JS, Mueller JR, Luo EC, Yee BA, Schafer D, Schmok JC, Tan FE, Rothamel K, McVicar RN, Kwong EM, Jones KL, Her HL, Chen CY, Vu AQ, Jin W, Park SS, Le P, Brannan KW, Kofman ER, Li Y, Tankka AT, Dong KD, Song Y, Carlin AF, Van Nostrand EL, Leibel SL, Yeo GW. Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions bioRxiv. 2022 Feb 23:2022.02.21.481223._x000D_ 8: Mutlu O, Ugurel OM, Sariyer E, Ata O, Inci TG, Ugurel E, Kocer S, Turgut-Balik D. Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach J Biomol Struct Dyn. 2022 Feb;40(2):918-930._x000D_ 9: Guo S, Lei X, Chang Y, Zhao J, Wang J, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F, Wang J, Cen S. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis Signal Transduct Target Ther. 2022 Dec 27;7(1):400._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34121407">10: Courouble VV, Dey SK, Yadav R, Timm J, Harrison JJEK, Ruiz FX, Arnold E, Griffin PR. Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics J Am Soc Mass Spectrom. 2021 Jul 7;32(7):1618-1630. </a>_x000D_ _x000D_ <strong>Products Related to SARS-CoV-2 NSP8 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>