AR antagonist 8
AR antagonist 8 (compound 16), an unnatural entestrane, is a potent Lupeol-inspired androgen receptor (AR) antagonist with an IC50 of 0.76 μM[1].
Product Specifications
UNSPSC
12352211
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ar-antagonist-8.html
Solubility
10 mM in DMSO
Smiles
O=C1CC[C@]([C@@](CC[C@]2(C)[C@]3([H])[C@H](C(C)=C)CC2)(C)[C@]3([H])CC4)([H])C4=C1
Molecular Formula
C22H32O
Molecular Weight
312.49
References & Citations
[1]Zachary D Stempel, et al. Function-Oriented Synthesis of Pentacyclic Triterpenoids and Discovery of an ent-Estrane as a Natural Product-Inspired Androgen Receptor Antagonist. Org Lett. 2024 Apr 19;26 (15) :3054-3059.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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