GPX4-IN-13
GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM).
Product Specifications
CAS Number
2644044-43-7
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-13.html
Smiles
O=C(C1=CC=C(C=C1)C#N)/C=C/C(C=CC=C2)=C2OC3=C(C=CC=C3)C=O
Molecular Formula
C23H15NO3
Molecular Weight
353.37
References & Citations
[1]Pamarthy, et al. "Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells." Drug Development Research 84.5 (2023) : 861-887.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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