RETRA (hydrobromide)

RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases[1].

Product Specifications

CAS Number

[1035875-01-4]

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/retra-hydrobromide.html

Smiles

O=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O.Br

Molecular Formula

C11H12BrNO3S2

Molecular Weight

350.25

References & Citations

[1]Kravchenko JE, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105 (17) :6302-7.