Atipamezole
Atipamezole (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM[1].
Product Specifications
CAS Number
104054-27-5
Product Name Alternative
MPV 1248
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/atipamezole.html
Purity
99.84
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CCC1(C2=CN=CN2)CC3=C(C=CC=C3)C1
Molecular Formula
C14H16N2
Molecular Weight
212.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Pertovaara A, et al.Pharmacological properties, central nervous system effects, and potential therapeutic applicationsof atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11 (3) :273-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor
Citation 01
Brain Res. 2020 Sep 15;1743:146949.|Eur J Neurosci. 2021 Apr 27.|Exp Mol Pathol. 2021 Feb;118:104587.|Front Cell Dev Biol. 2021 Mar 11:9:636327.|Research Square Preprint. 2022 May.|Sci Transl Med. 2023 Jan 18;15 (679) :eabq4064.|bioRxiv. 2024 November 03.|Protein Cell. 2019 Mar;10 (3) :178-195.
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