Dimethylenastron
Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC50 of 200 nM.
Product Specifications
CAS Number
863774-58-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dimethylenastron.html
Purity
98.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)CC(C)(C)C1
Molecular Formula
C16H18N2O2S
Molecular Weight
302.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Gartner M, et al. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. Chembiochem. 2005 Jul;6 (7) :1173-7.|[2]Sun XD, et al. Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta Pharmacol Sin. 2011 Dec;32 (12) :1543-8.|[3]Lüke J, et al. The effect of adjuvant dimethylenastron, a mitotic Kinesin Eg5 inhibitor, in experimental glaucoma filtration surgery. Curr Eye Res. 2010 Dec;35 (12) :1090-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP
Available Sizes
Frequently Asked Questions
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