Dimethylenastron

Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC50 of 200 nM.

Product Specifications

CAS Number

[863774-58-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dimethylenastron.html

Purity

98.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)CC(C)(C)C1

Molecular Formula

C16H18N2O2S

Molecular Weight

302.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Gartner M, et al. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. Chembiochem. 2005 Jul;6 (7) :1173-7.|[2]Sun XD, et al. Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta Pharmacol Sin. 2011 Dec;32 (12) :1543-8.|[3]Lüke J, et al. The effect of adjuvant dimethylenastron, a mitotic Kinesin Eg5 inhibitor, in experimental glaucoma filtration surgery. Curr Eye Res. 2010 Dec;35 (12) :1090-8.