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Sulfasalazine-d3,15N

Sulfasalazine-d3,15N is 15N and deuterated labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

Product Specifications

Product Name Alternative

NSC 667219-d3,15N

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; Ferroptosis; Isotope-Labeled Compounds; NF-κB

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

OC(C1=C(O)C([2H])=C([2H])C(/[15N]=N/C2=CC=C(S(=O)(NC3=NC=CC=C3)=O)C=C2)=C1[2H])=O

Molecular Formula

C18H11D3N3 15NO5S

Molecular Weight

402.40

References & Citations

[1]Wahl C, et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998 Mar 1;101 (5) :1163-74.|[2]Mao C, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593 (7860) :586-590.|[3]Sykes L, et al. Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes. Immunology. 2015 Dec;146 (4) :630-44.|[4]Chung WJ, et al. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. J Neurochem. 2009 Jul;110 (1) :182-93.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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