N-Butyl-N- (4-hydroxybutyl) nitrosamine

N-Butyl-N- (4-hydroxybutyl) nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N- (4-hydroxybutyl) nitrosamine is used to induce bladder cancer in rodents[1].

Product Specifications

CAS Number

[3817-11-6]

Product Name Alternative

BBN

UNSPSC

12352211

Hazard Statement

H302, H350

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-butyl-n-4-hydroxybutyl-nitrosamine.html

Purity

99.68

Solubility

DMSO : ≥ 100 mg/mL|H2O : 20 mg/mL (ultrasonic)

Smiles

CCCCN(N=O)CCCCO

Molecular Formula

C8H18N2O2

Molecular Weight

174.24

Precautions

H302, H350

References & Citations

[1]Zhiming He, et al. Tissue-specific mutagenesis by N-butyl-N- (4-hydroxybutyl) nitrosamine as the basis for urothelial carcinogenesis. Mutat Res. 2012 Feb 18;742 (1-2) :92-5.