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Philanthotoxin 74 dihydrochloride

Product Specifications

UNSPSC Description

Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively[1][2].

Target Antigen

iGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Philanthotoxin_74_dihydrochloride.html

Purity

98.47

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(NCCCCCCCNCCCCN)[C@@H](NC(CCC)=O)CC1=CC=C(O)C=C1.[H]Cl.[H]Cl

Molecular Weight

507.54

References & Citations

[1]Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8.|[2]Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45(26):5745-54.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-104020A/Philanthotoxin-74-dihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-104020A/Philanthotoxin-74-dihydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1227301-51-0

Available Sizes

Curated Selection

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