Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Philanthotoxin 74 dihydrochloride

Product Specifications

UNSPSC Description

Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively[1][2].

Target Antigen

iGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Philanthotoxin_74_dihydrochloride.html

Purity

98.47

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(NCCCCCCCNCCCCN)[C@@H](NC(CCC)=O)CC1=CC=C(O)C=C1.[H]Cl.[H]Cl

Molecular Weight

507.54

References & Citations

[1]Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8.|[2]Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45(26):5745-54.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-104020A/Philanthotoxin-74-dihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-104020A/Philanthotoxin-74-dihydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1227301-51-0

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Polybead® Microspheres 20.00µm
18329-5 5 mL

Polybead® Microspheres 20.00µm

Ask
View Details
NAALADL1 (NM_005468) Human Over-expression Lysate
LC417286 20 µg

NAALADL1 (NM_005468) Human Over-expression Lysate

Ask
View Details
Rabbit Polyclonal alpha-1D Adrenergic R/ADRA1D Antibody [Allophycocyanin]
NBP2-97580APC 0.1 mL

Rabbit Polyclonal alpha-1D Adrenergic R/ADRA1D Antibody [Allophycocyanin]

Ask
View Details
Mouse Transmembrane protein 225, TMEM225 ELISA Kit
MBS9333287-01 48 Well

Mouse Transmembrane protein 225, TMEM225 ELISA Kit

Ask
View Details
Mouse Transmembrane protein 225, TMEM225 ELISA Kit
MBS9333287-02 96 Well

Mouse Transmembrane protein 225, TMEM225 ELISA Kit

Ask
View Details
Mouse Transmembrane protein 225, TMEM225 ELISA Kit
MBS9333287-03 5x 96 Well

Mouse Transmembrane protein 225, TMEM225 ELISA Kit

Ask
View Details