Euphjatrophane M
Product Specifications
UNSPSC Description
Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that can reduce the phosphorylation of NF-κB p65 and has anti-inflammatory properties. Euphjatrophane M can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in RAW 264.7 macrophages induced by lipopolysaccharide (LPS, HY-D1056)[1].
Target Antigen
FOXO; Interleukin Related; NF-κB; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/euphjatrophane-m.html
Smiles
[H][C@]12CC([C@@]3(CC4=C(C(O[C@@]4(C[C@]3([C@@]1(CCCC2(C)C)C)[H])O)=O)C)[H])=O
Molecular Weight
332.43
References & Citations
[1]Ying Yan, et al. Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity. Bioorg Chem. 2024 Nov 22:154:107989.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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