Filorexant
Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor (<3 nM in binding) .
Product Specifications
CAS Number
[1088991-73-4]
Product Name Alternative
MK-6096
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MK-6096.html
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
Molecular Formula
C24H25FN4O2
Molecular Weight
420.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Winrow CJ, et al. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62 (2) :978-87.|[2]Coleman PJ, et al. Discovery of [ (2R,5R) -5-{[ (5-fluoropyridin-2-yl) oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2- (pyrimidin-2-yl) phenyl]methanone (MK-6096) : a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7 (3) :415-24, 337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
OX2 Receptor
Available Sizes
Curated Selection
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