Filorexant
Product Specifications
UNSPSC Description
Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).
Target Antigen
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MK-6096.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
Molecular Weight
420.48
References & Citations
[1]Winrow CJ, et al. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62(2):978-87.|[2]Coleman PJ, et al. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7(3):415-24, 337.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15653/Filorexant-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15653/Filorexant-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1088991-73-4
Available Sizes
Curated Selection
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