Filorexant

Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor (<3 nM in binding) .

Product Specifications

CAS Number

[1088991-73-4]

Product Name Alternative

MK-6096

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MK-6096.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1

Molecular Formula

C24H25FN4O2

Molecular Weight

420.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Winrow CJ, et al. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62 (2) :978-87.|[2]Coleman PJ, et al. Discovery of [ (2R,5R) -5-{[ (5-fluoropyridin-2-yl) oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2- (pyrimidin-2-yl) phenyl]methanone (MK-6096) : a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7 (3) :415-24, 337.