MDPR-Val-Cit-PAB-MMAE (TFA)
MDPR-Val-Cit-PAB-MMAE TFA is a drug-linker conjugate for ADC (Drug-Linker Conjugates for ADC), consisting of a tubulin polymerization inhibitor MMAE and an ADC linker (peptide Val-Cit- PAB) composition[1].
Product Specifications
CAS Number
2185872-76-6
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mdpr-val-cit-pab-mmae-tfa.html
Purity
99.51
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](N4C(C=CC4=O)=O)CN)=O)=O)=O)C=C3)=O)C)=O)=O)C.O=C(O)C(F)(F)F
Molecular Formula
C67H101F3N12O17
Molecular Weight
1403.58
References & Citations
[1]Moquist, et al. Preparation of drug conjugates of IgG1 antibodies with self-stabilizing linkers having improved physiochemical properties for treating cancers and autoimmune diseases. World Intellectual Property Organization, WO2018031690 A1. 2018-02-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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