Anti-KLK14 Antibody

Rabbit Polyclonal Antibody specific to KLK14

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

hK14, EC 3.4.21.-, Kallikrein-like protein 6, KLK-L6

Gene Name

KLK14

NCBI Gene ID

UniProt

Q9P0G3

Cellular Locus

Secreted, extracellular space

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 239-251 of human KLK14 protein.

Target Antigen

Kallikrein-14

Target

KLK14

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {PubMed:15654974, PubMed:16885167, PubMed:17158887, PubMed:17625593, PubMed:18056261, PubMed:18482984}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. A band of approximately 31 kD is detected.

Storage Conditions

This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes the gene product hk14 of human KLK14 (also known as KLK-L6), one of the many kallikrein serine proteases associated with carcinogenesis. KLK14 is expressed in normal and malignant glandular epithelial cells.