Dibenz[a, h]anthracene

Dibenz[a, h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a, h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a, h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms[1][2].

Product Specifications

CAS Number

[53-70-3]

Product Name Alternative

DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene

UNSPSC

12352005

Hazard Statement

H350, H410

Target

Apoptosis; DNA/RNA Synthesis; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dibenz-a-h-anthracene.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

C12=CC=CC=C1C3=CC(C=CC4=CC=CC=C45)=C5C=C3C=C2

Molecular Formula

C22H14

Molecular Weight

278.35

Precautions

H350, H410

References & Citations

[1]K L Platt, et al. Stereoselective metabolism of dibenz (a, h) anthracene to trans-dihydrodiols and their activation to bacterial mutagens. Environ Health Perspect. 1990 Aug:88:37-41.|[2]Amal I Malik, et al. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a, h]anthracene. Mutagenesis. 2013 Sep;28 (5) :543-54.