HDM-IN-1
HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model[1].
Product Specifications
CAS Number
3020690-76-7
UNSPSC
12352005
Target
Fungal; Histone Demethylase
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hdm-in-1.html
Smiles
COC(C=C1)=CN=C1N/N=C(C2=NC=CC=C2)\C3=NC=CC=C3
Molecular Formula
C17H15N5O
Molecular Weight
305.33
References & Citations
[1]Liu X, et al., Discovery of new fungal jumonji H3K27 demethylase inhibitors for the treatment of Cryptococcus neoformans and Candida auris infections. Eur J Med Chem. 2025 Jan 5;281:117028.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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