Oxindole

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

Product Specifications

CAS Number

[59-48-3]

Product Name Alternative

2-Indolinone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; HIV

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/NSC_274863.html

Purity

99.61

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1NC2=C(C=CC=C2)C1

Molecular Formula

C8H7NO

Molecular Weight

133.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014) . Expert Opin Ther Pat. 2016;26 (2) :149-73.|[2]Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894.