AP521
AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
Product Specifications
CAS Number
[151227-08-6]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AP521.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C([C@H]1CC(C2=CC=CC=C2S3)=C3CN1)NCC4=CC=C(OCO5)C5=C4.[H]Cl
Molecular Formula
C20H19ClN2O3S
Molecular Weight
402.89
References & Citations
[1]Kasahara K, et al. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. J Pharmacol Sci. 2015 Jan;127 (1) :109-16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3; MUC3; Prostaglandin D Synthase
Available Sizes
Curated Selection
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