Ampreloxetine (TFA)
Ampreloxetine (TD-9855) TFA is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine TFA has the potential for the research of neurogenic orthostatic hypotension[1][2].
Product Specifications
CAS Number
1227056-85-0
Product Name Alternative
TD-9855 (TFA)
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ampreloxetine-tfa.html
Purity
98.30
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=C(OCC2=CC=CC=C2C3CCNCC3)C(F)=CC(F)=C1.O=C(O)C(F)(F)F
Molecular Formula
C20H19F6NO3
Molecular Weight
435.36
References & Citations
[1]Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18 (2) :pyu027. |[2]Kaufmann H, et al. Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 trial. Clin Auton Res. 2021 Dec;31 (6) :699-711.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940270-500 1x 500 µL
Fibronectin (HFN7.1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400017-500 1x 500 µL
Ep-CAM / CD326 (VU-1D9), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041231-100 1x 100 µL
Eosinophil Peroxidase (AHE-1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742152-500 1x 500 µL
TACSTD2 / TROP2 (Epithelial Marker) (TACSTD2/2152), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details