P-gp/CDK2-IN-1
P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor for is inhibitor for P-glycoprotein (P-gp) and for cyclin-dependent kinase-2 (CDK2) . P-gp/CDK2-IN-1 inhibits the proliferation of cancer cells SW-480 and MCF-7 wit IC50 of 38.6 μM and 26.6 μM. P-gp/CDK2-IN-1 exhibits antioxidant efficacy with EC50 of 580 μM in DPPH experiment[1].
Product Specifications
UNSPSC
12352005
Target
CDK; P-glycoprotein
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-cdk2-in-1.html
Smiles
O=C(C1=C(N)OC(C=C(C)O2)=C(C2=O)C1C3=CC(OC)=C(OC)C(OC)=C3)OCC
Molecular Formula
C21H23NO8
Molecular Weight
417.41
References & Citations
[1]Ranjbar S, et al., 5-Oxo-dihydropyranopyran derivatives as anti-proliferative agents; synthesis, biological evaluation, molecular docking, MD simulation, DFT, and in-silico pharmacokinetic studies. Heliyon. 2024 Apr 23;10 (9) :e29850.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2
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