PI3K/mTOR Inhibitor-11

PI3K/mTOR Inhibitor-11 is an orally active PI3K/mTOR inhibitor (IC50: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR) . PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers[1].

Product Specifications

CAS Number

[2845104-25-6]

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-mtor-inhibitor-11.html

Concentration

10mM

Purity

99.65

Solubility

DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C1=NC=C(N2C(C)=NC3=C2C4=CC(C5=CN=C(NC=C6)C6=C5)=CC=C4N=C3)C=C1)(C)C#N

Molecular Formula

C27H21N7

Molecular Weight

443.50

References & Citations

[1]Yang J, et al. Discovery of 2-Methyl-2- (4- (2-methyl-8- (1H-pyrrolo[2,3-b]pyridin-6-yl) -1H-naphtho[1,2-d]imidazol-1-yl) phenyl) propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo. J Med Chem. 2022 Oct 13;65 (19) :12781-12801.