HDGFRP2/PSIP1-IN-1
HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG) . HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily[1].
Product Specifications
CAS Number
[166196-54-9]
Product Name Alternative
4- (4-Bromo-1H-pyrazol-5-yl) pyridine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdgfrp2-psip1-in-1.html
Concentration
10mM
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=CNN=C1C2=CC=NC=C2
Molecular Formula
C8H6BrN3
Molecular Weight
224.06
Precautions
H302, H315, H319, H335
References & Citations
[1]Xiaoli Wei, et al. Fragment-based discovery of small molecule inhibitors of the HDGFRP2 PWWP domain. FEBS Lett. 2024 Jul 19.1873-3468.14981.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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