Chloranil
Chloranil (Tetrachloro-p-benzoquinone), an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells[1][2][3][4][5] .
Product Specifications
CAS Number
118-75-2
Product Name Alternative
Tetrachloro-p-benzoquinone; TCBQ
UNSPSC
12352211
Hazard Statement
H315, H317, H318, H410
Target
Apoptosis; Ferroptosis; Fungal; JNK; MyD88; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chloranil.html
Purity
99.51
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(Cl)=C(Cl)C(C(Cl)=C1Cl)=O
Molecular Formula
C6Cl4O2
Molecular Weight
245.88
Precautions
H315, H317, H318, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR4
Available Sizes
Frequently Asked Questions
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