KAT8-IN-1

KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1].

Product Specifications

CAS Number

[605-62-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kat8-in-1.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C2C=CC=CC2=C([N+]([O-])=O)C=C1

Molecular Formula

C10H7NO3

Molecular Weight

189.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486.