Neutrophil elastase inhibitor 3
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1].
Product Specifications
CAS Number
[1234707-32-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/neutrophil-elastase-inhibitor-3.html
Purity
97.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OC(C2=CC=CC=C2Br)=NC3=CC=CC(Cl)=C13
Molecular Formula
C14H7BrClNO2
Molecular Weight
336.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem. 2010 Jul;45 (7) :3111-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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