Neutrophil elastase inhibitor 3

Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1].

Product Specifications

CAS Number

[1234707-32-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/neutrophil-elastase-inhibitor-3.html

Purity

97.23

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OC(C2=CC=CC=C2Br)=NC3=CC=CC(Cl)=C13

Molecular Formula

C14H7BrClNO2

Molecular Weight

336.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem. 2010 Jul;45 (7) :3111-5.