PAN endonuclease-IN-2
Product Specifications
UNSPSC Description
PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication[1].
Target Antigen
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pan-endonuclease-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C(CCC2=CC=C(O)C(O)=C2)=O)CC3=C(C=C(O)C(O)=C3)C1)OC4=C(Br)C=CC=C4Br
Molecular Weight
607.24
References & Citations
[1]Ruan J, et al. Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics. Bioorg Chem. 2024 Mar;144:107139.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158028/PAN-endonuclease-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158028/
Clinical Information
No Development Reported
Curated Selection
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