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PAN endonuclease-IN-2

PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication[1].

Product Specifications

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pan-endonuclease-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(C(CCC2=CC=C(O)C(O)=C2)=O)CC3=C(C=C(O)C(O)=C3)C1)OC4=C(Br)C=CC=C4Br

Molecular Formula

C25H21Br2NO7

Molecular Weight

607.24

References & Citations

[1]Ruan J, et al. Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics. Bioorg Chem. 2024 Mar;144:107139.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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