Barasertib-HQPA
Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells[1].
Product Specifications
CAS Number
722544-51-6
Product Name Alternative
AZD2811; INH-34; AZD1152-HQPA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Aurora Kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD1152-HQPA.html
Purity
99.33
Solubility
DMSO : ≥ 22 mg/mL
Smiles
O=C(CC1=NNC(NC2=C3C=CC(OCCCN(CCO)CC)=CC3=NC=N2)=C1)NC4=CC=CC(F)=C4
Molecular Formula
C26H30FN7O3
Molecular Weight
507.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13 (12) :3682-8.|[2]Yang, Jing., et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15;110 (6) :2034-40.|[3]Zekri A, et al. AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy. Tumour Biol. 2015 Feb;36 (2) :623-32.|[4]Oke A, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009 May 15;69 (10) :4150-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Aurora B
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940043-100 1x 100 µL
P21 / WAF1 (WA-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471231-100 1x 100 µL
Eosinophil Peroxidase (AHE-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681074-100 1x 100 µL
SOX10 (SOX10/991 + SOX10/1074), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881234-500 1x 500 µL
Bcl-2 (100/D5 + 124), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940262-500 1x 500 µL
Human Lambda Light Chain (HP6054), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details