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ITE

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.

Product Specifications

CAS Number

[448906-42-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/ITE.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CSC(C(C2=CNC3=C2C=CC=C3)=O)=N1)OC

Molecular Formula

C14H10N2O3S

Molecular Weight

286.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Song J, et al. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99 (23) :14694-9.|[2]Nugent LF, et al. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. Invest Ophthalmol Vis Sci. 2013 Nov 13;54 (12) :7463-9.|[3]Pang LP, et al. ITE inhibits growth of human pulmonary artery endothelial cells. Exp Lung Res. 2017 Oct;43 (8) :283-292.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-19317/ITE-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-19317/ITE-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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