Apaf-1 (Apoptosis Protease Activating Factor 1) (AP)

Product Specifications

Gene Name

[Apaf-1]

Reactivity

Human, C. elegans, Mammalian, Mouse

Storage Conditions

Store at 4 degree C. Do Not Freeze.

Specificity

Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C. Elegans. Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, resulting in the beginning of the proteolytic cascade characteristic of apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Recognizes a 130kD band in Western blots. Species Crossreactivity: Human, mouse