Xanthopterin (hydrate)

Xanthopterin hydrate, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin hydrate (XPT) causes renal growth and hypertrophy in rat[1]. Xanthopterin hydrate inhibits RNA synthesis[4].

Product Specifications

CAS Number

[5979-01-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/xanthopterin-hydrate.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1NC(N)=NC2=C1NC(C=N2)=O.O

Molecular Formula

C6H7N5O3

Molecular Weight

197.15

Precautions

H302, H315, H320, H335

References & Citations

[1]Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy.|[2]Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222 (1) :119-24.|[3]Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis) : light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85 (4) :955-61.|[4]Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365 (6) :667-73.