Dihydrokainic acid

Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory[1][2][3][4][5].

Product Specifications

CAS Number

[52497-36-6]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dihydrokainic-acid.html

Purity

99.0

Solubility

H2O : 5 mg/mL (ultrasonic)

Smiles

O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)C

Molecular Formula

C10H17NO4

Molecular Weight

215.25

Precautions

H302, H312, H332

References & Citations

[1]Lehmann A, et al. Dihydrokainic acid affects extracellular taurine and phosphoethanolamine levels in the hippocampus. Neuroscience Letters, 1983, 38 (1) : 67-72. |[2]Bouazzaoui M, et al. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Neurochem Res. 1996 Dec;21 (12) :1527-33.|[3]Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27 (4) :375-81.|[4]Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32.|[5]Muñoz M D, et al. Effects of dihydrokainic acid of extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology, 1987, 26 (1) : 1-8.